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Whipple Procedure

If you have pancreatic cancer, your care team might recommend the Whipple procedure as part of your treatment. The Whipple procedure, also called pancreaticoduodenectomy, is an operation that can treat pancreatic cancer found in the head of the pancreas. It is named after the surgeon, Dr. Allen Whipple, who pioneered the technique. 

It is considered the most effective treatment for pancreatic cancer but it’s not an option for everyone. It’s a complex operation that involves several different organs. Whipple surgery may also be done to treat other cancers in the same region, including cancers of the duodenum (first part of the small intestine) or bile duct.

In this procedure, a surgeon removes the head of the pancreas along with the duodenum, bile duct, gallbladder and sometimes part of the stomach. Then the surgeon reconnects everything so you can digest food properly.

There are a lot of steps involved in performing the Whipple procedure. If you need it, it is important to have it done at a specialized medical center where surgeons have done a high volume of these operations.

At Banner MD Anderson Cancer Center, our surgeons and care teams have extensive experience treating pancreatic and gastrointestinal cancers and performing the Whipple procedure. And they’re backed by our advanced cancer support services.

Who needs a Whipple procedure?

Not everyone qualifies for this procedure. It’s only an option for about 15% to 20% of people who have pancreatic cancer.

Your health care team may recommend this surgery if you have:

  • Pancreatic cancer (adenocarcinoma) in the head of the pancreas
  • Cancer in the bile duct, duodenum (first part of the small intestine) or ampulla, the place where the bile duct and pancreatic duct merge
  • Certain benign (non-cancerous) or precancerous tumors that could spread if they aren’t treated
  • Certain precancerous pancreatic cysts 
  • Ampullary cancer
  • Cholangiocarcinoma (bile duct cancer)
  • Pancreatic neuroendocrine tumors (pNETs)

You may not be a candidate for a Whipple procedure if the tumor surrounds major blood vessels in the region or if the cancer has already spread to other parts of the body.

Preparing for surgery

Before surgery, your care team may recommend imaging studies, lab tests, consultations with cancer care specialists and “prehabilitation” such as nutrition counseling and exercise recommendations. Banner MD Anderson provides a personalized care plan that factors in your unique needs.

How the Whipple surgery is performed

The Whipple procedure can be done as an open surgery or with minimally invasive robotic techniques, depending on your case. It may take four to 6 hours to perform.

During this complex operation, the surgeon:

  • Removes the head of the pancreas, duodenum, part of the bile duct and sometimes part of the stomach
  • Attaches the remaining pancreas, bile duct and stomach to the digestive system so food, bile and enzymes can flow normally
  • Removes nearby lymph nodes to check whether cancer has spread other areas
  • May have to work around or remove part of nearby blood vessels if the cancer is close to them

Risks and complications

Like all major surgeries, the Whipple procedure carries some risk. The most common include:

  • Leakage of pancreatic juice (pancreatic fistula)
  • Delayed gastric emptying, which is when the stomach takes longer than it should to empty food into the small intestine
  • Infection
  • Bleeding
  • Leakage of bile juice
  • Blood clots or pneumonia 
  • Diabetes

By choosing to have the procedure performed by an experienced team at a trusted medical center like Banner MD Anderson, you may lower these risks.

Recovery after the Whipple procedure

How long it takes you to recover depends on your overall health and any complications:

  • Most people stay in the hospital for five to six days after surgery if there are no complications. 
  • Some people occasionally need to stay in the intensive care unit (ICU) right after surgery.
  • You will consume only clear liquids at first and gradually move on to solid foods.
  • In the first weeks after surgery, your digestive system may work differently than before and you may need to make changes in what you eat.
  • Before leaving the hospital, your care team will review diet changes, wound care and follow-up appointments with you.

Going forward, you may need:

  • Daily pancreatic enzyme pills
  • Daily medication to reduce stomach acid
  • Blood sugar monitoring and possible diabetes medication

It can take a few months to fully recover but most people are able to return to their normal activities with the right support. At Banner MD Anderson, our ongoing care includes follow-up, nutrition guidance, programs for life after cancer and support for physical and emotional adjustments.

Additional treatment options

Because pancreatic and gastrointestinal cancers can be aggressive, your doctor may recommend other treatments after surgery, such as chemotherapy or radiation therapy, to make it less likely that the cancer will come back.

If you don’t qualify for a Whipple procedure, your provider will outline other options that are available to you. 

At Banner MD Anderson, a multidisciplinary team of surgeons, oncologists, gastroenterologists, and dietitians works with you to create a treatment plan that’s centered around your goals, needs and preferences.

We also offer access to clinical trials, so you have more options for advanced care that might not be available elsewhere.

Why choose Banner MD Anderson for a Whipple procedure?

Choosing where to have a Whipple procedure matters. At Banner MD Anderson, you benefit from our:

  • Experienced surgical teams that often operate on pancreatic and gastrointestinal cancers
  • Advanced techniques that help protect nearby blood vessels and support your recovery
  • Coordinated and integrated care across surgery, chemotherapy and radiation therapy and nutrition services
  • Long-term support from nurse navigators, social workers and survivorship programs for life after cancer
  • Access to clinical trials

Questions to ask your care team

How many Whipple surgeries do you perform each year? How many does your hospital perform?

  • Am I a good candidate for this surgery?
  • What risks should I be aware of?
  • Do you have a prehabilitation program?
  • How long will my stay in the hospital be and what will happen before I leave the hospital?
  • What resources are available for me after surgery?
  • Will I need chemotherapy or radiation therapy after surgery?
  • Are there any clinical trials I may qualify for?
  • What are my long-term survival expectations?
  • What will my recovery be like?
  • What support do you offer after surgery?

Take the next step

If you’ve been diagnosed with pancreatic cancer or another condition that could be treated with a Whipple procedure, you don’t have to face it alone. At Banner MD Anderson Cancer Center, our teams provide advanced care and compassionate support every step of the way. 

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