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Brain Biopsy

After finding out you have a brain tumor, your doctor may recommend a biopsy. During this procedure, a neurosurgeon takes a small sample of tissue from the lesion (abnormal area) for testing. The results help your care team confirm a diagnosis and guide decisions about next steps.

At Banner Health, we understand that waiting for answers can be difficult. Our experienced team of specialists will be by your side to help you understand your diagnosis, answer your questions and determine the next steps in your care. We take the time to understand your needs and create a plan that’s right for you.

When and why might I need a brain biopsy?

A brain biopsy is often done when doctors need more information about an abnormal area in the brain. Imaging tests, such as an MRI or CT scan, can show where the abnormal area is and what it looks like, but they might not always show what is causing it.

Your doctor might recommend a brain biopsy when:

  • Imaging alone cannot confirm the diagnosis: An MRI or CT scan can show an abnormal area in the brain but it might not identify exactly what it is.
  • The type of tumor will influence treatment: Different brain tumors may need different treatments. A tissue sample, obtained through a biopsy, can help your care team identify the tumor type, how it behaves and other key features.
  • The lesion cannot be safely removed: If the abnormal area is in a part of the brain where surgery could cause serious harm, a biopsy might be done to get important information without removing the whole lesion.
  • More information is needed before starting treatment: Biopsy results can help your care team decide whether surgery, radiation therapy, medication or other treatments are best.
  • A biopsy isn’t always necessary. Your care team will consider your symptoms, imaging results, overall health and the location of the abnormal area when deciding what to do next.

What tissue is removed in a brain biopsy?

During a brain biopsy, a neurosurgeon takes a small tissue sample from the abnormal part of the brain. The sample is examined by an expert pathologist to determine the diagnosis. Special molecular tests may also be performed to better understand the tumor’s characteristics, including how aggressive it may be.

Types of brain biopsy

There are two main types of brain biopsy: stereotactic needle biopsy and open biopsy. Your neurosurgeon will recommend the safest and most appropriate approach based on the location of the abnormal tissue and your overall health.

Stereotactic biopsy

A stereotactic needle biopsy uses advanced imaging and computer guidance to help your neurosurgeon reach a specific area of the brain. It is often used when the abnormal tissue is deep within the brain or in a difficult-to-reach area.

During the procedure:

  • Your surgeon makes a small opening in your skull
  • Imaging guides a thin biopsy needle to the targeted area
  • Your surgeon removes small tissue samples for testing

Open (surgical) biopsy

An open biopsy involves an operation called craniotomy. During craniotomy, a neurosurgeon temporarily removes a section of the skull to access the brain. The surgeon may remove a larger tissue sample or, when appropriate, remove part or all of the lesion during the same procedure.

An open biopsy is usually used when the lesion is not located in a deep area of the brain or near parts of the brain that control important functions.

How to prepare for a brain biopsy

Getting ready for a biopsy may take several weeks. During this time, your care team will give you instructions based on your procedure and health needs.

You may need to:

  • Have an MRI, CT scan or other imaging to locate the area being biopsied
  • Review all your medications with your doctor
  • Stop taking certain medications, including some blood thinners, before the procedure
  • Avoid eating or drinking for a certain amount of time before your biopsy
  • Arrange for someone to drive you home after the procedure
  • Have someone stay with you while you recover at home

Ask your care team any questions you have before your biopsy. Be sure to tell them about all medications and supplements you take.

What happens during a brain biopsy?

This kind of biopsy is done while you are under general anesthesia (asleep). In some cases, your doctor may recommend an awake brain biopsy to monitor important brain functions during the procedure.

During a brain biopsy, your neurosurgeon will:

  • Use imaging to identify the area that needs to be biopsied
  • Shave away a small amount of hair
  • Make a small opening to reach the targeted tissue
  • Use special tools and techniques to remove one or more small tissue samples
  • Close the incision (cut on your head)
  • Send the sample to a pathologist for testing

The procedure length depends on the biopsy type and the location of the abnormal tissue. Your doctor will explain what to expect before your procedure.

What to expect after a brain biopsy

Your recovery after a brain biopsy depends on the type of biopsy and your overall health. You might stay in the hospital for a short time so your care team can monitor you. Make sure someone can drive you home after you leave the hospital.

After the biopsy, you might feel nauseous, have a headache, some soreness or feel tired. These symptoms are usually mild and can be controlled with medicine.

Before you go home, you will receive instructions on how to care for yourself and which activities to avoid while you recover.

You might need to:

  • Limit activities like work, school, or exercise while you heal
  • Take your medicines as prescribed
  • Keep your incision clean and dry
  • Visit your neurosurgeon for a follow-up
  • Get follow-up scans if needed

Understanding your biopsy results

A pathologist examines your brain tissue sample to determine what is causing the abnormal area. Some results may be available within a few days. Additional testing may take longer.

Your neurosurgeon will review your results with you and explain what they mean. Depending on your diagnosis, your next steps may include:

  • Monitoring with imaging
  • Surgery
  • Radiation therapy
  • Medication
  • Seeing another specialist

Learn more about brain and skull base tumor treatment.

What are the risks of a brain biopsy?

Like any brain procedure, a brain biopsy has risks. These may include:

  • Bleeding
  • Infection
  • Seizures
  • Brain swelling
  • New neurological problems (weakness, numbness or difficulty speaking)

These problems may be temporary or, rarely, permanent. The specific risks depend in part on the location of the abnormal area and the type of biopsy. Your neurosurgeon will discuss your individual risks and benefits before the procedure.

When should I call my doctor?

Your care team will give you instructions on what to watch for after your biopsy. Call your care team if you have any questions or concerns about your recovery.

Get medical help right away if you have:

  • Severe or worsening headache
  • Fever
  • Redness, swelling or drainage from your incision
  • Increasing confusion
  • New weakness or numbness
  • Trouble speaking
  • Ongoing vomiting
  • A seizure

Call 911 or go to the nearest emergency room if your symptoms are severe or you believe you are having a medical emergency.

Brain biopsy at Banner Health

When you need a brain biopsy, you want an experienced team you can trust. At Banner Health, our neurosurgeons use advanced imaging tools and guided techniques to safely collect brain tissue for testing.

Your care is personalized to your diagnosis, the location of the abnormal tissue and your overall health. If you need more treatment, your neurosurgeon will work with other specialists like pathologists, neuro-oncologists and radiation oncologists to understand your results and plan your next steps.

From your diagnosis to follow-up, a team focused on your care will be with you every step of the way.

Find a doctor near you.

FAQs

Is a brain biopsy considered brain surgery?

Yes. A brain biopsy is a neurosurgical procedure.

Why might I need a brain biopsy?

A brain biopsy may be needed when imaging tests cannot confirm a diagnosis. Testing a small amount of tissue can help identify the condition and decide how to treat it.

How much brain tissue is taken?

Only a small amount of tissue is usually needed for a brain biopsy. Your neurosurgeon carefully targets the abnormal area to collect enough tissue for an accurate diagnosis and any additional testing that may help guide treatment.

Will I be awake during the biopsy?

Most brain biopsies are done while you are asleep under general anesthesia. Sometimes, the doctor may choose to do the biopsy while you are awake so they can check important brain functions.

How long does it take to recover?

Recovery time depends on the type of biopsy and your health. Your doctor will tell you when you can go back to normal activities.